Benzyl Bromide → HCID 5314864, compound

Participants

Reaction Steps

To a stirred solution of 2-naphthylacetic acid (1 g, 5.4 mmol) in acetonitrile (10 mL) were added DBU (0.97 mL, 6.4 mmol) and benzyl bromide (0.77 mL, 6.4 mmol). After 3 hours the mixture was concentrated, and the residue was taken up in ethyl acetate. The organic phase was washed with 10% citric acid, 10% NaHCO3 and brine, dried (MgSO4), and concentrated to give 2-naphthylacetic acid benzyl ester as a white solid (1.5 g, 100%).

Provenance & Evidence