HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 4-Bromo-2-methylbenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Bromo-2-methylbenzoic acid | HCID 99570 | — |
| Catalyst | Dichloromethane | HCID 6344 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-2-methylbenzoyl chloride | HCID 12846483 | — |
Reaction Steps
A suspension of 4-bromo-2-methylbenzoic acid (4.9 g, 22.8 mmol) in dichloromethane containing a few drops of N,N-dimethylformamide was treated dropwise under nitrogen with oxalyl chloride (2.4 mL, 27.5 mol). After gas evolution subsided, the reaction mixture was refluxed for an additional 15 minutes and then evaporated to dryness in vacuo to provide the crude 4-bromo-2-methylbenzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06268360B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-5dccd09901b84d3eb34b96fc57827b34 |
| Source note | uspto-grants-2001_07 |