反应详情

温度

50 °C

THF (2 ml) and bromoethane (0.1 ml) were added to magnesium (0.49 g, 0.02 mol) in a stream of nitrogen, and the mixture was stirred at 50° C. for 10 minutes. Then, a mixture of 1-bromo-2-(2,5-dimethylphenoxymethyl)benzene (2.91 g, 0.01 mol) and THF (8 ml) was added at 50 to 60° C. over 30 minutes, and the mixture was stirred at 50 to 60° C. for 1 hour. After completion of the reaction, the reaction mixture was added to a mixture of 3-methylisoxazol-5-carbonyl chloride (1.45 g, 0.01 mol) and THF (15 ml) at −70 to −60° C. over 15 minutes, and then the mixture was stirred at −70 to −60° C. for 0.5 hours. After completion of the reaction, saturated aqueous ammonium chloride solution (150 ml) was added, and the mixture was extracted with ether. The ether layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and the residue was purified by silica gel chromatography (ethyl acetate/n-hexane) and recrystallized from n-hexane to give 2-(2,5-dimethylphenoxymethyl)phenyl 3-methylisoxazol-5-yl ketone (0.56 g, 17.4%) as colorless crystals. mp. 106-108° C.

1. additionwas added at 50 to 60° C. over 30 minutes
2. stirringthe mixture was stirred at 50 to 60° C. for 1 hour
3. customAfter completion of the reaction
4. stirringthe mixture was stirred at −70 to −60° C. for 0.5 hours
5. additionwas added
6. extractionthe mixture was extracted with ether
7. dry with materialThe ether layer was dried over anhydrous magnesium sulfate
8. concentrationconcentrated under reduced pressure
9. customthe residue was purified by silica gel chromatography (ethyl acetate/n-hexane)
10. customrecrystallized from n-hexane