Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydracrylonitrile | HCID 8011 | — |
| Reactant | Ethyl 3-oxovalerate | HCID 78656 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 22725151 | HCID 22725151 | 73.5% |
Reaction Steps
A mixture of ethyl propionylacetate (25 g, 0.173 mol) and 3-hydroxypropionitrile (18.48 g, 0.26 mol) was stirred and heated at 200-205° C. for 2 h and the ethanol formed was removed by distillation. The residue was subjected to high vacuum distillation and the fraction distilling at 120-125° C. at 0.4 mm of Hg was collected to get 2-cyanoethyl propionylacetate (21.5 g, 73.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06268369B1 |
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| Source dataset | uspto-grants-2001_07 |
|---|
| ORD ID | ord-e3b383c488a54762871419138cbd2b20 |
|---|
| Source note | uspto-grants-2001_07 |
|---|
