3,5-Dichloro-4-hydroxybenzaldehyde → HCID 54207544, compound

HRID 1387414Notes

Reaction equation

HRID 1387414 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:14]=[C:15]([CH:18]=[C:19]([Cl:22])[C:20]=1[OH:21])[CH:16]=O>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[CH:16][C:15]3[CH:14]=[C:13]([Cl:12])[C:20]([OH:21])=[C:19]([Cl:22])[CH:18]=3)[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 168393,5-Dichloro-4-hydroxybenzaldehydeHCID 27732896-bromo-2,3-dihydro-1H-indol-2-one

Product 1

HCID 54207544HCID 54207544, compound

Procedure

The title compound is synthesized in an identical manner to example 2 except 6-bromo-oxindole was used in place of 5-(2-methyl-thiazol4-yl)-1,3-dihydro-indol-2-one hydrochloride and 3,5-dichloro-4-hydroxy-benzaldehyde was used in place of 3,5-dibromo-4a-hydroxy-benzaldehyde. 1H NMR (DMSO-d6) δ7.05 (s, 1H); 7.12 (d, 1H); 7.43 (d, 1H); 7.56 (s, 1H); 7.76 (s, 2H); 10.78 (bs, 1H); 10.91 (bs, 1H). Electrospray MS (−ve) 384.

Sources & evidence

ORD record
ord-11fa3ec63ce64c87b3e9d15243bf46a9
Source dataset
uspto-grants-2001_07
Patent number
US06268391B1

Reaction notes

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