L-Proline → HCID 15453762, compound

Participants

Reaction Steps

A mixture of 2-7 (430 mg, 1.18 mmol), 2-amino-3-formylpyridine (144 mg, 1.18 mmol; for prep., see JOC 1983,48, 3401) and proline (136 mg, 1.18 mmol) in absolute ethanol (20 mL) was heated at reflux for 12 h. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 50% ethyl acetate/chloroform—70:25:5 chloroform/ethyl acetate/MeOH) to give 2-8 as a yellow solid.

Provenance & Evidence