HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1387473Generated: October 26, 2026
Amantadine → 1-(3,4-Dichlorophenyl)-2-(1-adamantylamino)ethanol hydrochloride
https://huagongshe.com/reaction/1387473
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Amantadine | HCID 2130 | — |
| Reactant | 2-Bromo-1-(3,4-dichlorophenyl)ethanol | HCID 344136 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(3,4-Dichlorophenyl)-2-(1-adamantylamino)ethanol hydrochloride | HCID 19063954 | — |
Reaction Steps
27 g (0.1 mol ) of 1-(3,4-dichlorophenyl)-2-bromoethanol are added to a solution of 30 g (0.2 mol) of 1-adamantamine, 0.1 g of KI and 100 ml of ethanol; the mixture is stirred for 48 hours at 20° C. and 6 hours under reflux.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06268397B1 |
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| Source dataset | uspto-grants-2001_07 |
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| ORD ID | ord-8aafa581fdd34045945623146487db02 |
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| Source note | uspto-grants-2001_07 |
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