Dimethyl Sulfoxide → 3-Fluorobenzene-1,2-dicarbaldehyde

HRID 1387491Notes

Reaction equation

HRID 1387491 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7](F)=[CH:6][C:3]=1[CH:4]=[O:5].[S-2].[Li+].[Li+].[OH2:14].[CH3:15]S(C)=O>>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:15]=[O:14])[C:3]=1[CH:4]=[O:5]

Participants

5

Reactant 4

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 1376632,5-DifluorobenzaldehydeHCID 10290727Dilithium Sulfide

Product 1

HCID 223252303-Fluorobenzene-1,2-dicarbaldehydeYield 59%

Procedure

To a stirred solution of 17.5 g (123 mmol) of 2,5-difluorobenzaldehyde (Aldrich) in 615 mL of DMSO at ambient temperature was added 6.2 g (135 mmol) of lithium sulfide (Aldrich). The dark red solution was stirred at 75 C. for 1.5 hours, or until the starting material was completely consumed, and then 34 g (135 mmol) of dibutyl mesylate aldehyde was added at about 50 C. The reaction mixture was stirred at 75 C. for three hours or until the reaction was completed. The cooled solution was poured into water and extracted with ethyl acetate. The combined extracts were washed with water several times, dried (MgSO4) and concentrated in vacuo. Silica gel chromatographic purification of the crude product gave 23.6 g (59%) of fluorobenzene dialdehyde as a yellow oil: 1H NMR (CDCl3) d 0.87 (t, J=7.05 Hz, 6H), 1.0-1.4 (m, 8H), 1.5-1.78 (m, 4H), 3.09 (s, 2H), 7.2-7.35 (m, 1H), 7.5-7.6 (m, 2H), 9.43 (s, 1H), 10.50 (d, J=2.62 Hz, 1H).

Workup

  1. customuntil the starting material was completely consumed
  2. stirringThe reaction mixture was stirred at 75 C
  3. waitfor three hours
  4. extractionextracted with ethyl acetate
  5. washThe combined extracts were washed with water several times
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated in vacuo
  8. customSilica gel chromatographic purification of the crude product

Sources & evidence

ORD record
ord-ab4920a5eb904726976bd055c4392b40
Source dataset
uspto-grants-2001_07
Patent number
US06268392B1

Reaction notes

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