3-Amino-4-methoxybenzanilide → HCID 54481910, compound

HRID 1387536Notes

Reaction equation

HRID 1387536 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[S:28])=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27](=[S:28])[NH:1][C:2]2[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=2[O:17][CH3:18])[C:5]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:6])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 84263-Amino-4-methoxybenzanilideHCID 164804-Chlorophenyl isothiocyanate

Product 1

HCID 54481910HCID 54481910, compoundYield 87.9%

Procedure

Prepared according to the procedure described for Example 60 using 3-amino-4-methoxy-N-phenyl-benzamide (0.243 g, 1.0 mmol) and 4-chlorophenyl isothiocyanate (0.174 g, 1.03 mmol). Trituration in hexanes/ethyl acetate (1:1) gave the product (0.362 g); m.p. 179-180° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a7b616191a3d4ccab95175794e2d6c33
Source dataset
uspto-grants-2001_07
Patent number
US06268387B1

Reaction notes

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