3-Amino-4-methoxybenzanilide → HCID 54186783, compound

HRID 1387542Notes

Reaction equation

HRID 1387542 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[S:28])=[CH:22][C:21]=1[C:29]([F:32])([F:31])[F:30]>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27](=[S:28])[NH:1][C:2]2[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=2[O:17][CH3:18])[C:5]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:6])=[CH:22][C:21]=1[C:29]([F:30])([F:31])[F:32]

Participants

3

Reactant 2

HCID 84263-Amino-4-methoxybenzanilideHCID 5200261-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene

Product 1

HCID 54186783HCID 54186783, compoundYield 99.5%

Procedure

Prepared according to the procedure described for Example 60 using 3-amino-4-methoxy-N-phenyl-benzamide (0.972 g, 4.0 mmol) and 4-chloro-3-(trifluoromethyl)phenyl isothiocyanate (0.961 g, 4.0 mmol). Trituration in hexanes/ethyl acetate (3:2) gave the product (1.91 g); m.p. 172-173° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-905dd6ed98f243b88d5f5bfe0e0124a5
Source dataset
uspto-grants-2001_07
Patent number
US06268387B1

Reaction notes

Loading…