3-Amino-4-methoxybenzanilide → HCID 17921784, compound

HRID 1387548Notes

Reaction equation

HRID 1387548 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6].[F:19][C:20]([F:31])([F:30])[C:21]1[CH:22]=[C:23]([N:27]=[C:28]=[S:29])[CH:24]=[CH:25][CH:26]=1>>[CH3:18][O:17][C:16]1[CH:15]=[CH:14][C:4]([C:5]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:6])=[CH:3][C:2]=1[NH:1][C:28]([NH:27][C:23]1[CH:24]=[CH:25][CH:26]=[C:21]([C:20]([F:19])([F:30])[F:31])[CH:22]=1)=[S:29]

Participants

3

Reactant 2

HCID 84263-Amino-4-methoxybenzanilideHCID 1372321-Isothiocyanato-3-(trifluoromethyl)benzene

Product 1

HCID 17921784HCID 17921784, compoundYield 62.9%

Procedure

Prepared according to the procedure described for Example 60 using 3-amino-4-methoxy-N-phenyl-benzamide (0.972 g, 4.00 mmol) and 3-trifluoromethylphenyl isothiocyanate (0.82 g, 4.04 mmol). Trituration in hexanes/ethyl acetate gave the product (1.12 g) in two crops; m.p. 177-178° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6f237569c7344c6f9c66a5f90a2852ab
Source dataset
uspto-grants-2001_07
Patent number
US06268387B1

Reaction notes

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