3,5-Dichlorophenyl isothiocyanate → HCID 86583811, compound

HRID 1387564Notes

Reaction equation

HRID 1387564 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[O:19][CH3:20])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]([F:15])[CH:9]=1)=[O:6].[Cl:21][C:22]1[CH:23]=[C:24]([N:29]=[C:30]=[S:31])[CH:25]=[C:26]([Cl:28])[CH:27]=1>>[Cl:21][C:22]1[CH:23]=[C:24]([NH:29][C:30](=[S:31])[NH:1][C:2]2[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=2[O:19][CH3:20])[C:5]([NH:7][C:8]2[CH:13]=[CH:12][C:11]([F:14])=[C:10]([F:15])[CH:9]=2)=[O:6])[CH:25]=[C:26]([Cl:28])[CH:27]=1

Participants

3

Reactant 2

HCID 1387763,5-Dichlorophenyl isothiocyanateHCID 10755041HCID 10755041, compound

Product 1

HCID 86583811HCID 86583811, compoundYield 83.3%

Procedure

Prepared according to the procedure described for Example 60 using 3-amino-N-(3,4-difluorophenyl)-4-methoxy-benzamide from Example 15 (0.834 g, 3.00 mmol) and 3,5-dichlorophenyl isothiocyanate (0.6124 g, 3.00 mmol) to afford the product (1.206 g) in 3 crops; m.p. 180-183° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c6b58b439b8a49618b330ab40bf060ea
Source dataset
uspto-grants-2001_07
Patent number
US06268387B1

Reaction notes

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