HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-4-methoxybenzanilide → 3-(2,4-Difluoro-benzenesulfonylamino)-4-methoxy-N-phenyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-4-methoxybenzanilide | HCID 8426 | — |
| Reactant | 2,4-Difluorobenzenesulfonyl Chloride | HCID 2734273 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-(2,4-Difluoro-benzenesulfonylamino)-4-methoxy-N-phenyl-benzamide | HCID 18626262 | 84.4% |
Reaction Steps
Prepared according to the procedure described for Example 121 using 2,4-difluorobenzenesulfonyl chloride (2.19 g, 10 mmol), 3-amino-4-methoxy-N-phenyl-benzamide (2.43 g, 10 mmol), and pyridine (25 mL) to afford the product (3.532 g); m.p. 198-200° C. after trituration in hexanes/ethyl acetate (1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06268387B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-31c3ad0cde804b3dac517741818a19a8 |
| Source note | uspto-grants-2001_07 |