2-Naphthalenesulfonyl chloride → HCID 18626276, compound

HRID 1387586Notes

Reaction equation

HRID 1387586 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11](Cl)(=[O:13])=[O:12].[NH2:15][C:16]1[CH:17]=[C:18]([CH:28]=[CH:29][C:30]=1[O:31][CH3:32])[C:19]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:20]>N1C=CC=CC=1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:15][C:16]1[CH:17]=[C:18]([CH:28]=[CH:29][C:30]=1[O:31][CH3:32])[C:19]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:20])(=[O:13])=[O:12]

Participants

4

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 84263-Amino-4-methoxybenzanilide

Product 1

HCID 18626276HCID 18626276, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Prepared according to the procedure described for Example 121 using 2-napthalenesulfonyl chloride (2.28 g, 10 mmol), 3-amino-4-methoxy-N-phenyl-benzamide (2.43 g, 10 mmol), and pyridine (25 mL) to afford the product (4.139 g); m.p. 223-225° C. after trituration in hexanes/ethyl acetate (1:1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-24b7e901a10b422997d596d1c9c5d8b9
Source dataset
uspto-grants-2001_07
Patent number
US06268387B1

Reaction notes

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