p-Anisoyl chloride → HCID 18771459, compound

HRID 1387629Notes

Reaction equation

HRID 1387629 reaction equation
[C:1]([O:9][CH:10]([C:17]#[N:18])[C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:19][O:20]C1C=CC(C(Cl)=O)=CC=1>>[CH3:19][O:20][C:5]1[CH:4]=[CH:3][C:2]([C:1]([O:9][CH:10]([C:17]#[N:18])[C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[O:8])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 13812198HCID 13812198, compound

Product 1

HCID 18771459HCID 18771459, compound

Procedure

The title compound was prepared using the same procedure Lantos, I. et al. (J. Med. Chem. 1984, 27, 72-75) employed to prepare 1-cyano-1(4-pyridyl)-methyl benzoate, except using 4-methoxybenzoyl chloride: 1H NMR (CDCl3): d 8.81 (d, 2H); 8.10 (d, 2H); 7.57 (d, 2H); 7.01 (d, 2H); 6.74 (s, 1H); 3.93 (s, 3H).

Sources & evidence

ORD record
ord-40c3cb03680e473d8b7cc831e15a6d8d
Source dataset
uspto-grants-2001_07
Patent number
US06268370B1

Reaction notes

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