tert-Butyl carbazate → 1,1-Dimethylethyl 2-[[4-(2-pyridinyl)phenyl]methylene]hydrazinecarboxylate

HRID 1387680Notes

Reaction equation

HRID 1387680 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:14]=[CH:13][C:10]([CH:11]=O)=[CH:9][CH:8]=1.[C:15]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])(=[O:18])[NH:16][NH2:17]>>[C:20]([O:19][C:15]([NH:16][N:17]=[CH:11][C:10]1[CH:13]=[CH:14][C:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[CH:8][CH:9]=1)=[O:18])([CH3:23])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 70091tert-Butyl carbazateHCID 15152404-Pyridin-2-ylbenzaldehyde

Product 1

HCID 533949851,1-Dimethylethyl 2-[[4-(2-pyridinyl)phenyl]methylene]hydrazinecarboxylate

Procedure

WO97/40029 discloses a production method comprising reacting 4-(pyridin-2-yl)benzaldehyde with tert-butyl carbazate [tBuOC(═O)NHNH2 wherein tBu is tert-butyl] to give N-(tert-butoxycarbonyl)-N′-[4-(pyridin-2-yl)phenylmethylidene]hydrazine, therefor 4-(pyridin-2-yl)benzaldehyde is important as an intermediate for a pharmaceutical product.

Sources & evidence

ORD record
ord-1bbdf101b4094c8186a8631785b3f19c
Source dataset
uspto-grants-2001_07
Patent number
US06268503B1

Reaction notes

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