HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(2-(4-(Chloromethyl)phenoxy)ethyl)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | [4-(2-Piperidin-1-ylethoxy)phenyl]methanol | HCID 9816107 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 1-(2-(4-(Chloromethyl)phenoxy)ethyl)piperidine hydrochloride | HCID 9860785 | — |
Reaction Steps
The solution of 4-(2-piperidinyl-ethoxy)benzyl alcohol in ethylene dichloride can be combined with thionyl chloride and heated until the reaction is complete. Upon cooling, the mixture can be concentrated, followed by addition of 1,2-dimethoxyethane and additional concentration. The precipitate can be collected and dried to yield intermediate 4-(2-piperidinylethoxy)benzylchloride hydrochloride, as shown in Scheme IX.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06268504B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-2eef5e3dab634321890b89ad328949bc |
| Source note | uspto-grants-2001_07 |