Maleic Acid → 44742-89-4

Participants

Reaction Conditions

Reaction Steps

Trans-1-(N,N-dimethylamino)-3-(3′,4′-dichlorophenyl)indan (13 g, 0.042 mole) was dissolved in ethanol (60 mL) at 50° C. In a separate flask, maleic acid (4.95 g, 0.042 mol) was dissolved in 20 mL of ethanol at 50° C., then added to the solution of trans-1-(N,N-dimethylamino)-3-(3′,4′-dichlorophenyl)indan. The mixture was stirred at 50° C. for 1 h, then at 10° C. for 2 h. The precipitated product was collected by filtration, then washed with cold ethyl acetate (40 mL). The solid was dried under high vacuum to give 13.8 g (77%) of N,N-dimethyl [3-(3′,4′-dichlorophenyl) indan-1-γ1] ammonium hydrogen maleate. The ratio of the undesired cis isomer was 0.3% as detected by HPLC.

Provenance & Evidence