HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1387802Generated: October 31, 2026
4-Cyanopyridine → 4-Cyano-1-[4-(7-phenyl-3,4-dihydronaphthalene-2-carboxamido)benzyl]pyridinium chloride
https://huagongshe.com/reaction/1387802
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Cyanopyridine | HCID 7506 | — |
| Reactant | N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide | HCID 10809385 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Cyano-1-[4-(7-phenyl-3,4-dihydronaphthalene-2-carboxamido)benzyl]pyridinium chloride | HCID 18472409 | 78.8% |
Reaction Steps
In DMF (3 ml) was dissolved N-[4-(chloromethyl)-phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide (140 mg), and to the mixture was added 4-cyanopyridine (117 mg). The mixture was stirred at 70° C. for 24 hours and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-methanol to give 4-cyano-1-[4-(7-phenyl-3,4-dihydronaphthalene-2-carboxamido)benzyl]pyridinium chloride (Compound 21) (141 mg) as pale brown crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06268354B1 |
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| Source dataset | uspto-grants-2001_07 |
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| ORD ID | ord-7da0871fef9e410a96d9ac2ef703e93a |
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| Source note | uspto-grants-2001_07 |
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