Methyl iodide → 1-Methyl-1-(4-(3-(4-methoxyphenyl)cinnamoylamino)benzyl)piperidinium iodide

Participants

Reaction Steps

A solution of 1-(4-(3-(4-methoxyphenyl)cinnamoyl-amino)benzyl)piperidine (0.32 g) and methyl iodide (0.2 ml) in dimethylformamide (5 ml) was stirred at room temperature over night. The solvent was evaporated, and to the residue was added ethyl acetate. Precipitated crude crystal was filtered, which were recrystallized from ethanol-hexane to give 1-methyl-1-(4-(3-(4-methoxyphenyl)cinnamoylamino)-benzyl)piperidinium iodide (Compound 88) (0.33 g) as pale brown crystals.

Provenance & Evidence