HCID 18472333, compound → HCID 18472283, compound

HRID 1387920Notes

Reaction equation

HRID 1387920 reaction equation
[CH3:1][O:2][C:3]1[C:4]([CH:9]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)[OH:10])=[N:5][CH:6]=[CH:7][CH:8]=1>C(O)C.[Pd]>[NH2:17][C:14]1[CH:13]=[CH:12][C:11]([CH:9]([C:4]2[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[CH:6][N:5]=2)[OH:10])=[CH:16][CH:15]=1

Participants

4

Reactant 1

HCID 18472333HCID 18472333, compound

Product 1

HCID 18472283HCID 18472283, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of (3-methoxypyridin-2-yl)-(4-nitro-phenyl)methanol (600 mg) and 5% Pd—C (0.06 g) in ethanol (20 ml) was vigorously stirred under hydrogen atmosphere for 3 hours, and the Pd—C was filtered off. The filtrate was concentrated under reduced pressure to give (4-aminophenyl)-(3-methoxypyridin-2-yl)-methanol (483 mg) as pale yellow crystals.

Workup

  1. filtrationthe Pd—C was filtered off
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c52cf45e1c1d4fa18defb2b6fa5a5a62
Source dataset
uspto-grants-2001_07
Patent number
US06268354B1

Reaction notes

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