HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Nitrobenzyl)phosphorinane-1-oxide → 1-(4-Aminobenzyl)phosphorinane-1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Nitrobenzyl)phosphorinane-1-oxide | HCID 18472224 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(4-Aminobenzyl)phosphorinane-1-oxide | HCID 22989986 | 75.6% |
Reaction Steps
A mixture of 1-(4-nitrobenzyl)phosphorinane-1-oxide (2.25 g) and 10% Pd—C (0.2 g) in ethanol (30 ml) was vigorously stirred under hydrogen atmosphere for 24 hours. The catalyst was filtered off, and the filtrate was concentrated recrystallized from ethanol-diethylether to give 1-(4-aminobenzyl)-phosphorinane-1-oxide (1.5 g) as pale yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06268354B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-e33970d97fe947f293dd9a220a15e84e |
| Source note | uspto-grants-2001_07 |