2-Amino-5-bromobenzenemethanol → 2-Amino-5-bromobenzaldehyde

HRID 1388068Notes

Reaction equation

HRID 1388068 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH2:9][OH:10]>[O-2].[O-2].[Mn+4].CC(C)=O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH:9]=[O:10]

Participants

4

Reactant 1

HCID 110308742-Amino-5-bromobenzenemethanol

Product 1

HCID 235104752-Amino-5-bromobenzaldehydeYield 71.1%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 180AcetoneSolvent

Procedure

To acetone (300 ml) were added (2-amino-5-bromophenyl)methanol (23.32 g) and active manganese dioxide (58.5 g), and the mixture was stirred at room temperature for 17.5 hours and filtered. The solvent was evaporated under reduced pressure to give 2-amino-5-bromobenzaldehyde (16.41 g, 71%).

Workup

  1. filtrationfiltered
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-7534fa7cd9d54a15922c298c7dc382ef
Source dataset
uspto-grants-2001_07
Patent number
US06268354B1

Reaction notes

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