Benzene → 1-(1-methyl-1-phenyl-2-propynyloxy)-2-(N-pyrrolidinyl)-3-phenoxy propane

Participants

Reaction Steps

27.5 g of 1-pyrrolidinyl-2-chloro-3-phenoxy propane were gradually introduced into a reactor containing 29.2 g of 2-phenyl-3-butyne-2-ol, 20 g of sodium hydroxide in 20 ml of water and 2.27 g of benzyl triethylammonium, while stirring well. When the addition ended, the reaction medium was very thick and 20 ml of benzene were added before refluxing for 5 hours. The product was then extracted with ether, filtered, washed and dried as indicated in Example 1.

Provenance & Evidence