Potassium Hydroxide → HCID 13231126, compound

HRID 1388113Notes

Reaction equation

HRID 1388113 reaction equation
[C:1]([CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16]([NH:19]C(OCC)=O)[CH2:15][CH2:14]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>C(O)C.O>[C:1]([CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16]([NH2:19])[CH2:15][CH2:14]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 13231125HCID 13231125, compound

Product 1

HCID 13231126HCID 13231126, compoundYield 114.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

30.0 g of 4-(4-benzoylbutyl)-1-(ethoxycarbonylamino)piperazine was dissolved in 250 ml of ethanol, and a solution of 50.5 g of potassium hydroxide in 50 ml of water was added. The mixture was heated under reflux for 3 hours. Ethanol was evaporated, and water was added. Extraction with chloroform gave 27.0 g of the title compound. The hydrochloride of this product had a melting point of 213° to 215° C. (decomp.).

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. customEthanol was evaporated
  4. additionwater was added
  5. extractionExtraction with chloroform

Sources & evidence

ORD record
ord-bee0b6cb802d4d378f8532de8ae9cd47
Source dataset
uspto-grants-1984_02
Patent number
US04430342

Reaction notes

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