HCID 13187608, compound → HCID 13187611, compound

Participants

Reaction Steps

5.0 g of 4-(4-benzoylbutyl)-1-(cyanomethylamino)piperazine dihydrochloride was dissolved in 50 ml of water, and under ice cooling, a solution of 2.0 g of sodium nitrite in 20 ml of water was added dropwise. The reaction was carried out for 1 hour. The reaction mixture was extracted with chloroform. Chloroform was evaporated, and the residue was dissolved in 30 ml of methanol. Then, 30 ml of 12% ethanolic hydrochloric acid was added, and the reaction was carried out for two days at room temperature. The precipitated crystals were collected by filtration to give 3.7 g of the title compound having a melting point of 168° C. (decomp.).

Provenance & Evidence