Potassium Hydroxide → HCID 54300978, compound

Participants

Reaction Steps

A solution of 13.5 g of potassium hydroxide in 160 ml of ethanol is added dropwise in the course of one hour and while stirring to 68 g of (3-cyclohexylpropyl)-malonic acid diethyl ester (prepared analogously to Example 4d), dissolved in 160 ml of ethanol. After stirring for 24 hours at room temperature, the mixture is concentrated considerably in vacuo and the residue is dissolved in 400 ml of water and extracted with 300 ml of diethyl ether. 40 ml of half-concentrated hydrochloric acid are added to the aqueous phase, while cooling with ice, and the mixture is extracted with 3 times 300 ml of diethyl ether. The combined organic phases are dried over sodium sulphate and concentrated. This gives 51 g of (3-cyclohexylpropyl)-malonic acid ethyl ester in the form of a viscous, yellowish oil.

Provenance & Evidence