HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylhomopiperazine → Emedastine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylhomopiperazine | HCID 228349 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | 2-chloro-1-(2-ethoxyethyl)-1H-benzimidazole | HCID 10489356 | — |
| Product | Emedastine | HCID 3219 | — |
Reaction Steps
In the same manner as described in Example 1 using 2-chloro-1-[2-(ethoxy)ethyl]benzimidazole (3.00 g), N-methylhomopiperazine (3.10 g) and fumaric acid (2.63 g), ther are obtained crude crystals, which are recrystallized from ethyl acetate-ethanol to give 1-[2-(ethoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole.difumarate (3.78 g) as colorless needles, m.p. 141°-143° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04430343 |
| Source dataset | uspto-grants-1984_02 |
| ORD ID | ord-7062adf2730f4b1ba33bbc33e7b310dd |
| Source note | uspto-grants-1984_02 |