1-Methylhomopiperazine → 87250-52-0

HRID 1388166Notes

Reaction equation

HRID 1388166 reaction equation
Cl[C:2]1[N:6]([CH2:7][CH2:8][O:9][CH2:10][CH2:11][CH3:12])[C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[N:3]=1.[CH3:17][N:18]1[CH2:24][CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29]>>[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29].[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29].[CH2:10]([O:9][CH2:8][CH2:7][N:6]1[C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[N:3]=[C:2]1[N:21]1[CH2:22][CH2:23][CH2:24][N:18]([CH3:17])[CH2:19][CH2:20]1)[CH2:11][CH3:12]

Participants

4

Reactant 3

HCID 2283491-MethylhomopiperazineHCID 444972Fumaric AcidHCID 13623328HCID 13623328, compound

Product 1

HCID 644843187250-52-0Yield 59.3%

Procedure

In the same manner as described in Example 1 using 2-chloro-1-[2-(n-propoxy)ethyl]benzimidazole (2.83 g), N-methylhomopiperazine (3.00 g) and fumaric acid (2.04 g), there are obtained crude crystals, which are recrystallized from ethyl acetate-ethanol to give 1-[2-(n-propoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate (2.86 g) as colorless needles, m.p. 159.5°-160.5° C.

Workup

  1. customare obtained crude crystals, which
  2. customare recrystallized from ethyl acetate-ethanol

Sources & evidence

ORD record
ord-8273bb6d1a6241c7bb672bc994047e7d
Source dataset
uspto-grants-1984_02
Patent number
US04430343

Reaction notes

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