1-Methylhomopiperazine → 1H-Benzimidazole, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1-(2-phenoxyethyl)-, (E)-2-butenedioate (1:2)

Participants

Reaction Steps

In the same manner as described in Example 1 using 2-chloro-1-[2-(phenoxy)ethyl)benzimidazole (4.00 g), N-methylhomopiperazine (4.00 g) and fumaric acid (2.65 g), there are obtained crude crystals, which are recrystallized from ethanol to give 1-[2-(phenoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate (3.50 g) as colorless needles, m.p. 167°-168° C.

Provenance & Evidence