HRID1388229

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10928

Ethyl chloroformate

C3H5ClO2

结构：CCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)Nc1cc(Cl)c(N)cc1O

HCID20036192

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)Nc1cc(O)c(NC(=O)C(CC)Oc2ccc(C(C)(C)CC)cc2C(C)(C)CC)cc1Cl

HCID20471931

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

42 g of the 5-amino-4-chloro-2-[2-(2,4-di-tert-amylphenoxy)butanamido]phenol obtained in Step (i) above was dispersed in acetonitrile to which 10.4 g of ethyl chloroformate was added dropwise under refluxing. After refluxing for 3 hours, the reaction mixture was cooled to deposite crystals. The crystals were collected by filtration and dried to obtain 41.8 g of the above described compound.

WORKUP

后处理

additionwas added dropwise
temperatureunder refluxing
temperatureAfter refluxing for 3 hours
temperaturethe reaction mixture was cooled to deposite crystals
filtrationThe crystals were collected by filtration
customdried
customto obtain 41.8 g of the

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d18690cbd9534404bf141d0c25842912
来源数据集: uspto-grants-1984_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04430423
来源说明: uspto-grants-1984_02

反应 SMILES

[NH2:1][C:2]1[C:3]([Cl:32])=[CH:4][C:5]([NH:9][C:10](=[O:31])[CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([CH2:24][CH3:25])([CH3:23])[CH3:22])=[CH:17][C:16]=2[C:26]([CH2:29][CH3:30])([CH3:28])[CH3:27])[CH2:12][CH3:13])=[C:6]([OH:8])[CH:7]=1.Cl[C:34]([O:36][CH2:37][CH3:38])=[O:35]>C(#N)C>[CH2:37]([O:36][C:34]([NH:1][C:2]1[C:3]([Cl:32])=[CH:4][C:5]([NH:9][C:10](=[O:31])[CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([CH2:24][CH3:25])([CH3:23])[CH3:22])=[CH:17][C:16]=2[C:26]([CH2:29][CH3:30])([CH3:28])[CH3:27])[CH2:12][CH3:13])=[C:6]([OH:8])[CH:7]=1)=[O:35])[CH3:38]