Water → HCID 54281195, compound

Participants

Reaction Steps

28.2 g of 2-amino-4-chloro-5-nitrophenol was refluxed in 150 ml of acetonitrile and a solution containing 52.7 g of 2-dodecanesulfonamidobenzoyl chloride obtained in Step (i) above dissolved in 50 ml of acetonitrile was added to the mixture. After refluxing for 4 hours, the reaction mixture was cooled to deposit the crystals. The crystals were collected by filtration, washed with acetonitrile, and dried to yield 56 g thereof. The crystals were refluxed with stirring for 1 hour together with 60 g of reduced iron powder, 2 g of ammonium chloride, 50 g of water, and 500 ml of isopropanol. After removing the iron powder by filtration, the filtrate was poured into 2 liters of water to deposit the crystals. The crystals were collected by filtration and recrystallized from acetonitrile to obtain 36 g of the above described compound.

Provenance & Evidence