Water → 2-(4-Methylphenyl)quinazolin-4(3H)-one

Participants

Reaction Steps

A mixture of 2'-carbamoyl-p-toluanilide (66.97 g; 0.263 mol), sodium hydroxide (41.9 g) and water 837 ml) is stirred and heated at reflux for 0.5 hour. The resultant solution is cooled down, made acid with acetic acid. The reaction mixture is filtered, the isolated product is washed and dried to afford 58.16 g off white solid, mp 239°-241° C. Recrystallized from absolute ethanol, the product has a mp of 239°-240.5° C.

Provenance & Evidence