Diazomethane → HCID 86739237, compound

HRID 1388266Notes

Reaction equation

HRID 1388266 reaction equation
[CH3:1][C:2]1([CH3:14])[C@@H:4](/[CH:5]=[CH:6]/[C:7]([O:9][CH3:10])=[O:8])[C@H:3]1[C:11]([OH:13])=[O:12].[N+](=[CH2:17])=[N-]>C(Cl)Cl.C(Cl)(Cl)Cl>[CH3:1][C:2]1([CH3:14])[C@@H:4](/[CH:5]=[CH:6]/[C:7]([O:9][CH3:10])=[O:8])[C@H:3]1[C:11]([O:13][CH3:17])=[O:12]

Participants

5

Reactant 2

HCID 9550DiazomethaneHCID 18609509HCID 18609509, compound

Product 1

HCID 86739237HCID 86739237, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6344DichloromethaneSolvent

Procedure

Using the procedure of Example 7, 1.26 g of (1R,cis) 2,2-dimethyl-3-[(E)-3-methoxy-3-oxo-1-propenyl]-cyclopropane-1-carboxylic acid and 12.7 ml of 0.5 M/l of diazomethane in methylene chloride were reacted to obtain 0.678 g of methyl (1R,cis) 2,2-dimethyl-3-[(E)-3-methoxy-3-oxo-1-propenyl]-cyclopropane-1-carboxylate with a specific rotation of [α]D20 =-4°±2° (c=0.6% in chloroform).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f107d2e84e8d4035829020791c0be19a
Source dataset
uspto-grants-1984_02
Patent number
US04431576

Reaction notes

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