O-methyl-N,N'-diisopropylisourea → HCID 86739248, compound

HRID 1388277Notes

Reaction equation

HRID 1388277 reaction equation
[CH3:1][C:2]1([CH3:15])[C@@H:4](/[CH:5]=[C:6]2/[C:7](=[O:11])[S:8][CH2:9][CH2:10]/2)[C@H:3]1[C:12]([OH:14])=[O:13].[CH:16](NC(=NC(C)C)OC)(C)C>C(O)C>[CH3:1][C:2]1([CH3:15])[C@@H:4](/[CH:5]=[C:6]2/[C:7](=[O:11])[S:8][CH2:9][CH2:10]/2)[C@H:3]1[C:12]([O:14][CH3:16])=[O:13]

Participants

4

Reactant 2

HCID 383824O-methyl-N,N'-diisopropylisoureaHCID 18596288HCID 18596288, compound

Product 1

HCID 86739248HCID 86739248, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using the procedure of Example 17, 4.5 g of (1R,cis) 2,2-dimethyl-3-[(E) (dihydro-2-oxo-3-(2H)-thienylidene)-methyl]-cyclopropane-1-carboxylic acid and 3.5 g of methyl N,N'-diisopropylcarbamimidate were reacted to obtain 2.2 g of methyl (1R,cis) 2,2-dimethyl-3-[(E) (dihydro-2-oxo-3-(2H)-thienylidene)-methyl]-cyclopropane-1-carboxylate with a specific rotation of [α]D20 =+63.5°±1.5° (c=1.1% in ethanol).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-7d4f7e9ebc8645ce8a70a3e74cc3e105
Source dataset
uspto-grants-1984_02
Patent number
US04431576

Reaction notes

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