Diketene → HCID 13048326, compound

HRID 1388293Notes

Reaction equation

HRID 1388293 reaction equation
[CH3:1][NH:2][C@@H:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C@H:4]1[OH:12].[CH2:13]=[C:14]1[O:18][C:16](=[O:17])[CH2:15]1>C(O)C>[CH3:1][N:2]([C@@H:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C@H:4]1[OH:12])[C:16](=[O:17])[CH2:15][C:14]([CH3:13])=[O:18]

Participants

4

Reactant 2

HCID 12661DiketeneHCID 11557337HCID 11557337, compound

Product 1

HCID 13048326HCID 13048326, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of trans-2-methylamino-1-indanol (4.9 g, 0.03 m) in 100 ml of ethanol was added 2.8 g (0.033 m) of diketene. After stirring about 1 hour the mixture was concentrated to dryness in vacuo. The residue was dissolved in acetonitrile and the solvent was evaporated in vacuo to 6.3 g (85%) of an oily residue which was used directly in the next step.

Workup

  1. concentrationwas concentrated to dryness in vacuo
  2. dissolutionThe residue was dissolved in acetonitrile
  3. customthe solvent was evaporated in vacuo to 6.3 g (85%) of an oily residue which

Sources & evidence

ORD record
ord-2fe6a16885bd4b969dfddcdd51fde975
Source dataset
uspto-grants-1984_02
Patent number
US04431647

Reaction notes

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