HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 20470805, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chloromethyl methyl sulfide | HCID 16916 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-(4-Hydroxy-1-oxo-2,3-dihydro-1H-inden-2-yl)acetamide | HCID 20470798 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | HCID 20470805 | HCID 20470805 | — |
Reaction Steps
To 2-acetylamino-4-hydroxy-1-indanone 10.25 g (0.05 m) in 50 ml of dry HMPA under N2 is added 2.6 g (0.055 m) of a 50% oil dispersion of sodium hydride in portions. After stirring at room temperature for 1/2 hr, 5.3 g (0.055 m) of chloromethyl methyl sulfide is added, and the mixture is stirred overnight. Water is added and the mixture is extracted with ethyl acetate which is back-washed with water. After drying (Na2SO4) and concentration, the desired product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04431647 |
| Source dataset | uspto-grants-1984_02 |
| ORD ID | ord-21ab3372c1144164aa28c71bf92e7848 |
| Source note | uspto-grants-1984_02 |