Ammonia → HCID 13186354, compound

HRID 1388303Notes

Reaction equation

HRID 1388303 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([CH2:14][S:15](Cl)(=[O:17])=[O:16])[N:13]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[NH3:19]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([CH2:14][S:15]([NH2:19])(=[O:17])=[O:16])[N:13]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 13186363HCID 13186363, compound

Product 1

HCID 13186354HCID 13186354, compound

Procedure

The sulfonyl chloride intermediate prepared in Step C above (15.3 g., 0.049 mol) was allowed to react with concentrated ammonia (150 ml) at room temperature for 10 minutes. On filtration there was obtained 8.75 g. of sulfonamide intermediate, m.p. 165°-167° C. Recrystallization from tetrahydrofuran-ether-petroleum ether gave m.p. 168°-170° C. Anal. Calc'd. for C10H8Cl2N2O2S2 : % C, 37.16; % H, 2.49; % N, 8.67. Found: % C, 37.13; % H, 2.36; % N, 8.36.

Workup

  1. filtrationOn filtration there
  2. customwas obtained 8.75 g
  3. customRecrystallization from tetrahydrofuran-ether-petroleum ether
  4. customgave m.p. 168°-170° C

Sources & evidence

ORD record
ord-57e9ef88edc94796a241fdd34f11f2b3
Source dataset
uspto-grants-1984_02
Patent number
US04431652

Reaction notes

Loading…