Water → HCID 13186359, compound

Participants

Reaction Steps

To a solution of the ethyl oxamate intermediate prepared in Step E above (4.4 g., 0.010 mol) in dimethylformamide (26 ml) was added potassium tert-butoxide (3.5 g., 0.032 mol) in portions over 15 minutes. After stirring overnight, the reaction mixture was poured into water (250 ml). Acidification with 6 N hydrochloric acid, followed by filtration, yielded 3.5 g. of crude product. Recrystallization from tetrahydrofuran-ether-petroleum ether gave 1.74 g. of the title compound, m.p. 301° C. (dec.).

Provenance & Evidence