1,4-Dichlorobutane → 2-(4-Chloro-1-butyl)-3(2H)-benz[d]isothiazolone 1,1-Dioxide

HRID 1388328노트

반응식

HRID 1388328 반응식
[S:1]1([C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:5](=[O:6])[NH:4]1)(=[O:3])=[O:2].[Na].[Cl:14][CH2:15][CH2:16][CH2:17][CH2:18]Cl>CN(C)C=O>[Cl:14][CH2:15][CH2:16][CH2:17][CH2:18][N:4]1[C:5](=[O:6])[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=2[S:1]1(=[O:2])=[O:3]

참가 물질

4

반응물 2

HCID 80591,4-DichlorobutaneHCID 24181110Benzosulfinide sodium; Garantose sodium

생성물 1

HCID 132898002-(4-Chloro-1-butyl)-3(2H)-benz[d]isothiazolone 1,1-Dioxide수율 12.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Sodium saccharin (5.6 g, 0.027 mole) and 1,4-dichlorobutane (14.9 ml, 0.135 mole) were taken into 100 ml of dimethylformamide and heated on a steam bath for 4 hours. The reaction mixture was evaporated in vacuo to an oil and the oil extracted with 100 ml of hexane. Residual hexane was removed from the remaining oil by vacuum evaporation to yield the title product (956 mg).

후처리

  1. temperatureheated on a steam bath for 4 hours
  2. customThe reaction mixture was evaporated in vacuo to an oil
  3. extractionthe oil extracted with 100 ml of hexane
  4. customResidual hexane was removed from the remaining oil by vacuum evaporation

출처 및 근거

ORD 기록
ord-7b392e00ed75481e8579882cd3e22f04
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431646

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