Phenethyl bromide → HCID 20470947, compound

HRID 1388354Notes

Reaction equation

HRID 1388354 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]23[C:15](=[O:16])[CH2:14][CH:13]2[CH2:12][NH:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1.Br[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1>[CH2:18]([N:11]1[CH2:10][C:9]2([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:13]([CH2:14][C:15]2=[O:16])[CH2:12]1)[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 7666Phenethyl bromideHCID 10340Sodium CarbonateHCID 20470943HCID 20470943, compound

Product 1

HCID 20470947HCID 20470947, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In the manner of Example 9, 5-(m-methoxyphenyl)-3-azabicyclo[3.2.0]heptan-6-one, dimethyl acetal can be reacted with 1-bromo-2-phenylethane and sodium carbonate in toluene to give 3-phenethyl-5-(m-methoxyphenyl)-3-azabicyclo[3.2.0]heptan-6-one, dimethyl acetal.

Sources & evidence

ORD record
ord-623e0a2f25e94089b921e160fdd21c1b
Source dataset
uspto-grants-1984_02
Patent number
US04431661

Reaction notes

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