Toluene → HCID 20470935, compound

Participants

Reaction Steps

A mixture of 1.18 g. of 3-methyl-5-(m-methoxyphenyl)-3-azabicyclo[3.2.0]heptan-6-one, 0.78 g. of 2,2-dimethyl-1,3-propanediol and 1.05 g. of p-toluenesulfonic acid in 25 ml. of toluene was heated at reflux under a Dean-Stark trap for 29 hours. The mixture was cooled, diluted with ether, washed with 10% sodium hydroxide, and then with water giving a brown oil. This oil was distilled in a Kugelrohr apparatus at 175° C. and 0.10 mm., giving the desired product as a colorless oil.

Provenance & Evidence