Dimethyl Sulfate → 68256-20-2

HRID 1388362Notes

Reaction equation

[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH:9][C:10](=[O:25])[C:11]1[CH:16]=[C:15]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])[C:14]([Cl:22])=[CH:13][C:12]=1[O:23][CH3:24])[CH3:2].S(OC)(O[CH3:30])(=O)=O>>[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH:9][C:10](=[O:25])[C:11]1[CH:16]=[C:15]([N:17]([CH3:30])[S:18]([CH3:21])(=[O:20])=[O:19])[C:14]([Cl:22])=[CH:13][C:12]=1[O:23][CH3:24])[CH3:2]

Participants

Reactant 2

HCID 6497Dimethyl Sulfate

HCID 305197868256-41-7

Product 1

HCID 305197368256-20-2

Procedure

Using N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-4-chloro-5-methanesulfonamidobenzamide and dimethyl sulfate, the reaction is effected as in Example 5, whereby N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-4-chloro-5-(N-methylmethanesulfonamido)benzamide is obtained as crystals melting at 140.5° to 142° C.

Sources & evidence

ORD record: ord-6a0a5ab250cf49cf834e2dac7cf733d2
Source dataset: uspto-grants-1984_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04431663

Reaction notes

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