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Tetrafluoro-m-phenylenediamine dihydrochloride → 4-[2-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl)ethyl]piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| 反応物 | 4,5,6,7-tetrahydro-2[2-(4-pyridyl)ethyl]-1H-1,3-diazepine | HCID 13281194 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Adams' catalyst | HCID 345198 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-[2-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl)ethyl]piperidine | HCID 20239752 | 76.7% |
反応手順
The 4,5,6,7-tetrahydro-2[2-(4-pyridyl)ethyl]-1H-1,3-diazepine (1.9 g, 0.009 M) and PtO2 (0.25 g) in ethanol (20 ml) and 2 NHCl (15 ml) was reduced at 45 psig of hydrogen. After the hydrogenation, the solvent was removed and the residue was crystallized from ethanol-ether to give 1.5 g of 4-[2-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl)ethyl]piperidine (60% yield) as dihydrochloride salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04431653 |
| 出典データセット | uspto-grants-1984_02 |
| ORD ID | ord-32b68b0809ab4b06845167deb23addad |
| 出典メモ | uspto-grants-1984_02 |