HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1H-Imidazol-2-yl)pyridine → 3-(1H-imidazol-2-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1H-Imidazol-2-yl)pyridine | HCID 12395500 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(1H-imidazol-2-yl)piperidine | HCID 13281195 | 108% |
Reaction Steps
3-(1H-imidazol-2-yl)pyridine (4.0 g, 0.0275 M) and platinum oxide (0.5 g) in ethyl alcohol (50 ml) and 1 NHCl (50 ml) was reduced at 45 psig of hydrogen for 4 hrs. The reaction mixture was filtered and the filtrate was stripped to dryness and crystallized from MeOH-EtOH to give 3-(1H-imidazol-2-yl)piperidine (4.5 g, 74% yield, mp 295° dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04431653 |
| Source dataset | uspto-grants-1984_02 |
| ORD ID | ord-7492b5ce1c714456bcefe0ca1551538b |
| Source note | uspto-grants-1984_02 |