Sodium ethoxide → HCID 13281207, compound

Participants

Reaction Conditions

Reaction Steps

A mixture containing 4(cyanomethyl)-1-piperidinecarboxaldehyde (3.5 g, 0.023 M) and 1,2-diamino-2-methylpropane mono-p-toluenesulfonate (12.4 g, 0.047 M) was heated at 185° C. under nitrogen for 5 hrs. The reaction mixture was dissolved in ethanol (20 ml), basified with sodium ethoxide (0.052 M), filtered and stripped to dryness. The residue was distilled at 150° C. to about 185° C., 0.02 mmHg, to give (3.1 g, 63%) 4-[(4,5-dihydro-5,5-dimethyl-1H-imidazol-2-yl)methyl]-piperidine.

Provenance & Evidence