HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiourea → Ethyl 2-(2-aminothiazol-4-yl)-2-pentyloxyiminoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Sodium Acetate Trihydrate | HCID 23665404 | — |
| Reactant | Ethyl 4-chloro-3-oxo-2-[(pentyloxy)imino]butanoate | HCID 53992771 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 2-(2-aminothiazol-4-yl)-2-pentyloxyiminoacetate | HCID 54426052 | 52.1% |
Reaction Steps
Ethyl 2-pentyloxyimino-3-oxo-4-chlorobutyrate (syn isomer) (51.1 g.) and thiourea (14.7 g.) were reacted in the presence of sodium acetate trihydrate (26.4 g.) in a mixture of water (125 ml.) and ethanol (175 ml.) according to a similar manner to that of Preparation 8-(10) to give crystals of ethyl 2-pentyloxyimino-2-(2-amino-1,3-thiazol-4-yl)acetate (syn isomer) (28.7 g.), mp 86° to 88° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04431643 |
| Source dataset | uspto-grants-1984_02 |
| ORD ID | ord-927ce10fec9f4155bbd7783eaf404ddf |
| Source note | uspto-grants-1984_02 |