反应详情

To a cold (-2°), stirred solution of 285 g. (2.26 mol) of 2-fluoroanisole in 1.1 L of acetic anhydride was added, dropwise, 114 mL of fuming nitric acid (sp. gr. 1.59) at such a rate that the reaction temperature remained between -2° and 0°. The reaction mixture was stirred for 5 hours at this temperature then poured into 4.0 L of water. The suspension was stirred for 1.5 hours, stored for 15 hours, then extracted with methylene chloride (2×1.0 L). The combined extracts were washed with water (2×500 mL), dried over anhydrous magnesium sulfate, then concentrated in vacuo (475 g.). Crystallization from ethanol gave 147.4 g. (38%) of material suitable for further transformation. Additional material (34.5 g.) was obtained from three scouting runs.

1. customremained between -2° and 0°
2. stirringThe reaction mixture was stirred for 5 hours at this temperature
3. stirringThe suspension was stirred for 1.5 hours
4. extractionextracted with methylene chloride (2×1.0 L)
5. washThe combined extracts were washed with water (2×500 mL)
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated in vacuo (475 g.)
8. customCrystallization from ethanol
9. customgave 147.4 g
10. customAdditional material (34.5 g.) was obtained from three scouting runs