反应详情

A solution of 4-methoxyphenol (5.76 g, 46.5 mmol) and KOH (2.61 g, 46.6 mmol) in 2-ethoxyethanol (90 mL) was heated with removal of water until the pot temperature reached 130° after which time 4-methyl-5-chloro-6-methoxy-8-nitroquinoline, prepared as in Example 1 (9 g, 35.7 mmol), was added. The reaction mixture was heated at reflux (130°) for 2 hours and cooled at 5° for 18 hours. Filtration afforded the title compound (8.25 g, 68%), mp 158°-60°.

1. customreached 130°
2. additionwas added
3. temperatureThe reaction mixture was heated
4. temperatureat reflux (130°) for 2 hours
5. temperaturecooled at 5° for 18 hours
6. filtrationFiltration