1,2,3,4-Tetrahydro-2-naphthalenol → 1,2,3,4-Tetrahydronaphthalen-2-yl methanesulfonate

HRID 1388584노트

반응식

HRID 1388584 반응식
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[OH:11].[CH3:12][S:13](Cl)(=[O:15])=[O:14]>N1C=CC=CC=1>[CH3:12][S:13]([O:11][CH:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1]1)(=[O:15])=[O:14]

참가 물질

4

반응물 2

HCID 107471,2,3,4-Tetrahydro-2-naphthalenolHCID 31297Methanesulfonyl chloride

생성물 1

HCID 218878371,2,3,4-Tetrahydronaphthalen-2-yl methanesulfonate수율 54.8%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-tetralinol (0.86 g) in pyridine (5 ml) was stirred with cooling to 0°. Methylsulphonyl chloride (0.8 g) was added dropwise while maintaining the temperature at 0°. The mixture was then allowed to warm to room temperature and was stirred for 0.5 hour. The mixture was then poured on to ice and immediately a white precipitate formed; the mixture was allowed to stand overnight. The precipitate was then filtered off, washed with water and air-dried to give 2-methylsulphonyloxytetralin (0.72 g), m.p. 60°-62°.

후처리

  1. temperaturewith cooling to 0°
  2. temperaturewhile maintaining the temperature at 0°
  3. additionThe mixture was then poured on to ice
  4. customimmediately a white precipitate formed
  5. waitto stand overnight
  6. filtrationThe precipitate was then filtered off
  7. washwashed with water
  8. customair-dried

출처 및 근거

ORD 기록
ord-a14519104c1c4040be8a92b82b59ab6c
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431834

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